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Effect of vitamin E on chemotherapy induced oxidative stress and immunoglobulin levels in patients with acute myeloid leukemia | ||
| Medical Journal of Tikrit | ||
| Article 1, Volume 1, Issue 141, 2012, Pages 146-151 | ||
| Authors | ||
| Imad A-J Thanoon; Anwar Sheikha; Khalid N. Mustafa | ||
| Abstract | ||
| To assess the effects of acute myeloid leukaemia (as a disease), the chemotherapy and the addition of vitamin E as an antioxidant on oxidative stress parameters(total antioxidant status , serum albumin , ferritin, ceruloplasmin) and immunoglobulin levels (IgA, IgM, IgG), in patients with acute myeloid leukaemia The study was conducted in the Medical City in Baghdad, between Nov.2004 and April 2007. Fifty individuals were included in this study, twenty-five patients with acute myeloid leukaemia and 25 age and sex matched apparently healthy subjects taken as a control for the initial laboratory tests. Initially for both the patients and control groups the following parameters were assayed, total antioxidant status , serum albumin , ferritin , ceruloplasmin and immunoglobulin levels (IgA, IgM, IgG).For the patient group after receiving chemotherapy, the same parameters were assayed, later after a 30 day course of vitamin E (400 IU/day) as an antioxidant, the parameters were also measured. Initially, there was a highly significant differences (P<0.001) in the serum levels of ferritin, in patients with acute myeloid leukaemia before cytotoxic therapy and in comparison with control’s result . After having the specific cytotoxic regimen , there was a significant reduction in total antioxidant status , serum albumin , ferritin ,ceruloplasmin and immunoglobulins (IgA, IgM, IgG), in comparison to pre-chemotherapy results. After a course of vitamin E, there was a significant raise in serum total antioxidant status, serum albumin, ceruloplasmin and immunoglobulin with a significant reduction in serum ferritin, in comparison to postchemotherapy results | ||
| Keywords | ||
| Effect of vitamin E on chemotherapy induced oxidative stress and immunoglobulin levels in patients with acute myeloid leukemia | ||
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