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Correlations among Serum Oxidant / Antioxidant Parameters in Asthma | ||
| Medical Journal of Tikrit | ||
| Article 1, Volume 1, Issue 131, 2012, Pages 84-90 | ||
| Authors | ||
| Mossa M. Marbut; Abdul Ghani Mohamed Al Samarai; Amina Hamed Ahmad Al Obaidi | ||
| Abstract | ||
| Many studies suggest that levels of oxidative stress are increased in children and in adults with asthma, not only in their lungs but also in the circulation. A total of 127 asthmatic patients (64 symptomatic and 63 asymptomatic, 24 intermittent, and 20 patients with either persistent atopic or persistent non atopic asthma.) included in the study. In all asthma group there was a significant inverse correlation between serum levels of uric acid, albumin, bilirubin, FEV1 and lactate. However, there were a significant positive correlation between uric acid and albumin serum levels; uric acid serum levels FEV1 predicted percent; albumin serum levels and FEV1 predicted percent; albumin and bilirubin serum levels; bilirubin serum levels and FEV1 predicted percent. For all asthma groups, TAC significantly correlated with uric acid, albumin serum levels and FEV1. While there was a significant inverse correlation between TAC and lactate levels. The same pattern of correlations was achieved for the above mentioned parameters in asymptomatic asthma group but with higher significance. There was a significant multiple correlations between TAC, albumin, uric acid, bilirubin, lactate serum levels, and FEV1 in asthmatic group. Treatment of asthma with beclomethasone dipropionate and salbutamol reduced serum MDA and increased TAC mean levels significantly. Although treatment with corticosteroids inhaler and salbutamol for the duration of one month reduced lipid peroxidation and increased TAC significantly, it was still at levels significantly higher for MDA and lower for TAC than healthy control. Thus the treatment may need a longer duration to improve lipid peroxidation or an alternative regimen which is more effective in controlling inflammation may be warranted. | ||
| Keywords | ||
| Correlations among Serum Oxidant | ||
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