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Experimental induction of delay union in femur bone fracture and itseffect on the adjacent skeletal muscles | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 5, Issue 2, 2009, Pages 160-168 | ||
| Author | ||
| Ban Ismael Seddeek | ||
| Abstract | ||
| Bone fracture and its healing process have been extensively investigated for many years. in this studybone delayed.union and its effect on the adjacent muscle was investigated. Ten local breed adult rabbitsof both sexes weighing 1200-1500 g were used in the experiment. A11 animals were undergoing surgicaloperations to induce a transverse closed fracture in the midshaft of the femur, All animals were survivedfor five months' and then killed using high dose inhalation of chloroform inside glass box. The surgicaiprocedures were made under (general anesthesia) of 50mg/kg Ketamin hydrochloride. A 5 cmlongitudinal incision was made on the lateral side of the right thigh. the fractured bone were fixed usingintramedullary fixati.on). Approximate the two fragments and a gap of about 2.5-3 mm length was left toprevent normal bone union. The length and weight of each muscle were measured. Comparison betweenright and left side for both weight and length was made. A specimen from the muscles of anterior groupof thigh (i.e. Rectus femoris), posterior group of thigh (i.e. biceps femoris), anterior group of ieg(i.e.tibia1is anterior), and posterior group of leg (i.e. soleus) for both right and left was taken. Sample alsofrom fracture site was taken. Staining of sections using Haematoxylin and eosin.the result reveaied asignificant decrease in muscle libers weight and diameters. It was concluded that the delay in bonehealing reflected on recovery of the weight and diameter of adjacent skeletal muscle f,rbers. | ||
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