Phytochemical analysis and antibacterial activity of some medicinal plantsagainst methicillin-resistant Staphylococcus aureues

N. Darogha, Suhaila

	Phytochemical analysis and antibacterial activity of some medicinal plantsagainst methicillin-resistant Staphylococcus aureues
Tikret Journal of Pharmaceutical Sciences
Article 1, Volume 5, Issue 2, 2009, Pages 116-126
Author
Suhaila N. Darogha
Abstract
Tlre objective of this study is, first to report the prevalence of methicillin resistant Staphylococcusaureues (MRSA) infections and their antibiotic susceptibility patterns in Teaching and EmergencyHospital in Erbil city, and second to screen four medicinal plants: Eucalyptus globulus, Anethuntgraveolens, Prosopis farcta and Ficus carica (both aqueous extract and ethanolic extract) for potentialantibacterial activity against MRSA isolates, then screening the phytochemical properlies of these plants.Out of total 1 10 strains of Staphylococcus aureues isolated from different clinical specimens, 5 (13.6%)were found to be methicillin resistant. All MRSA strains were found to be resistant to penicillin andgentamycin while 86.66% were resistant to cephalothin ,doxycyciin and tobramycin. However, no strainswere resistant to vancomycin. Determination of rninimal inhibitory concentration (MIC) and minimalbactericidal concentration (MBC) values were performed using micro broth dilution method. TheMIC/,IBC of aqueous and ethanolic extracts of E. gtobulzus against MRSA isolates were 25112.5 mg/mland 6.2513.125 mg/ml respectively, while of P. farcta werc 100125 mg/ml and 25112.5 mg/mlrespectively. The results also revealed that extracts of F. carcia were inactive against MRSA. Preliminaryphytochemical analysis revealed the presence of tannins and phenols in almost all the crude extractsfollowed by alkaloids and resins, while the glycosides was not detected in any extracts of the four plantstested.

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