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Differential Study of Antimicrobial Activity of Vancomycin andTeicoplanin (Targocid) against Strains of Staphylococcus aureus^ndStreptococci sp. | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 5, Issue 2, 2009, Pages 203-207 | ||
| Author | ||
| Waseem Ali Hasan | ||
| Abstract | ||
| The glycopeptide antibiotics vancomycin and teicoplanin (targocid) are widely used in the treatment ofinfections caused by gram positive bacteria. Vancomyc inhibits both transglycosylation andtranspeptidation reaction during peptidoglycan assembly, targocid inhibits peptidoglycan polymerization,resulting in inhibition of bacterial cell wall synthesis and cell death. In this study twenty strains ofstreptococcus pyogenes and streptococcus pneumoniae and twenty five strains of staphylococcus a?lreuswere collected from different infections. MICs and MBCs of vancomycin and targocid were determinedagainst the bacterial strains, the MICs of vancomycin for the streptococcus strains were 4-8 pg /mlcompared with 8-16 pg/ml for targocid and MICs of targocid for staphylococcus aureus were 4-16 ltglmlMBC for the same strains were 8-32 pg/ml. the conclusion of this study was that targocid was less activethan vancomycin against staphylococci but equal or more active against streptococci specifically itpresents excellent in vitro activity against streptococcus pneumonio strains. | ||
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