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Synthesis of some new ,3-oxazepine derivativesand evaluation of antibacterial activitv | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 5, Issue 2, 2009, Pages 147-155 | ||
| Authors | ||
| Gazwan H.A. Al-Somaidaie; Ismeel Y. Majeed; Ibtisam K. Jassim | ||
| Abstract | ||
| This paper contained the synthesis of some new derivatives of 1,2,4-ttazole ring from thereactions of 3-amino 1,2,4-triazole derivatives (I) with different substituted benzaldehyde(in absolute .ethanol with present glacial acetic acid as catalyst) to prepare Schiff bases(IIa-c). The prepared new Schiff bases (IIa-c) reacted with maleic anhydride or 2-nitrophthalic anhydride in dry benzene to give oxazepines compounds (IIIa-e) (7-memberedring). The synthesized compounds were elucidated by some spectroscopy methods (IR,UV and Elemental analysis (C.H.N)) besides the TLC was used to check the products.Tire biological activities of some prepared compounds (IIa, IIIa-e) were also studiedasainst four different kinds of bacteria. | ||
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