Al-joubory, A., -S- Hamad, A. (2010). Preparation of2 - thio ether - 1, 3, 4- oxadiuzole derivatives used asantibacterial and antifungus agents. , 6(2), 169-179.
Abed-M-Daher Al-joubory; Ayad -S- Hamad. "Preparation of2 - thio ether - 1, 3, 4- oxadiuzole derivatives used asantibacterial and antifungus agents". , 6, 2, 2010, 169-179.
Al-joubory, A., -S- Hamad, A. (2010). 'Preparation of2 - thio ether - 1, 3, 4- oxadiuzole derivatives used asantibacterial and antifungus agents', , 6(2), pp. 169-179.
Al-joubory, A., -S- Hamad, A. Preparation of2 - thio ether - 1, 3, 4- oxadiuzole derivatives used asantibacterial and antifungus agents. , 2010; 6(2): 169-179.

Preparation of2 - thio ether - 1, 3, 4- oxadiuzole derivatives used asantibacterial and antifungus agents

Tikret Journal of Pharmaceutical Sciences
Article 1, Volume 6, Issue 2, 2010, Pages 169-179
Authors
Abed-M-Daher Al-joubory; Ayad -S- Hamad
Abstract
lsonicotinic acid, o-hydroxy benzoic acid, p-chlorobenzoic acid, p-nitro benmicacid ando-acetyl be1120ic acid, have been csterificated wilh absolute ethanol using Fisher methodto prepare compov11ds [1 -~). TileSby the reaction with hydrazinc hydrate. Tile acid hydrazides were ~llowed to react withcmbon disulfide (CS2) in th~ presence of potassium hydroxide and ethanol to produce 2-substitutetl I, 3, 4- oxndiazolc -5-thiol [11 - 15). Thio ether derivatives as two groups (16-20) and (21·25) respectively huve been prepared by the reaction between compounds fl l-15) and alk')'l or aryl halide, {p-bromo benzyl bromide anrl 2,4- dinitrochlorobenzene)respectively. The prepared compounds wac identified by FT.l.R , melting point and H'NlviRwas used to support tbe structure of tllc compounds 2·(4-cl>lorophenyl)-5-(2,4-dinltrophcoyl thio )·1,3 ,4 -oKaoxadiazolc which c;m be used as anti bacterial and anti fungus agents.
Statistics
Article View: 95
PDF Download: 50


Journal Management System. Powered by iJournalPro.com