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Formulation ancl Evaluation of a Topical Antioxidant Preparation | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 3, Issue 2, 2007, Pages 152-169 | ||
| Authors | ||
| Hassan Ahmed Hassan; Emad Muthana Yousif; Ali Ahmed Yas | ||
| Abstract | ||
| The aim of this work was to prepare the stable vitamin C rvater/oilirvater (w/o/w)multiple emulsions, to investigate the usage of poloxamine 908, to observe the influence ofsurfactant percentage on the properties of multiple emulsions. Multiple emulsions were prepared byliquid paraffin, cetyl dimethicone copolyol and poloxamine 908 by a two - step emulsificationprocedure. Vitamin C r,vas used as an antioxidant and r,vater - soluble model. The viscosity,conductivity and globule size of multiple emulsions rvere follor,ved over time. The formulationscontaining 1o/o cetyl dimethicone copolyol and I or Zoh poloxamine 908 lvere the most stablesystems. The globule size of multiple emulsions ranged from 20 to 37 pm and did not changeduring time. The yield of multiple en-rulsions rvas betrveen 99.6Yo and 98.7o/o. The conductivityincreased and the viscosity of systems decreased during time. Increase in poloxamine 908influenced the viscosity of the system, rvith the viscosity decreasing as the hydrophitic surfactantconcentrations were increased. Vitamin C rclease lronr the multiple emulsions u'as slow'; the releaservas aft'ccted by both surlactant concentratior.rs. Poloxanrirre 908 could be used as a hydrophilicsurfactant for formulation of rv/o/rv multiple emulsions. The concentration of poloxanrine 908 was avery important parameter in preparing stable multiple enrulsions. It 'uvas concluded that vitamin Cmight be transported out by molecular diffusion and through a reverse micellar mechanismcontrolled by the viscosity of the system | ||
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