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Endocrine Disturbances in Polycy'stic Ovary Sy'ndrome | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 3, Issue 2, 2007, Pages 117-121 | ||
| Authors | ||
| Aydin Siddiq Ahmed; Pinar Haqqi Tahir | ||
| Abstract | ||
| Polycystic ovary syndrome (PCOS) is a heterogeneolls disorder of unknorvn aetiologyaffecting 5-10% of rvomen of reproductive age. It is a disorder that affects the reproductive,endocrine and metabolic systems, and it is the most comnlon caLrse of anovulatory infertility. Thepurpose of this study is to nvestigate the endocrine clistr.rrbance in PCO. Tu'o hundred infertilelvomen attended Infertility Unit in Kirkuk rvere sr"rbjected to this study. Their ages range betrveen 17and 4T years (30.5 * 6.89) rvith average duration of infertility at the time of the study rvas (7 .23 year+ 4.60). Trventy volunteer healtiry fertile women of same age range as subjected inlertile patients,rvith no clinical evidence of endocrine abnormalities n'ere subjected to the stucll'as a control group.The immunoradiometric assay of the follicle simulating honnone (FSH), luteinizing ltormone (LH),LH: FSI-I ratio, prblactin and progesterone hornrortes w'ere carriecl out on samples obtained fro eachindividual. Regarding tire endocrinal evaluation in PCOS cases, our results revealed that meanvalues of senrnr LI-I, FSH and prolactin l*'cls u'ere significantll'(P<0.05) elevatccl in most womenri'hcr slrorved PCO and they reachcd 35.7t) lull- * 5.i66 ,15.89 lUlL * 4.228 ancl 21.84 ng/L *9.5i4. LLI:FSI{ ratio also shor.r'ed a significant (p<0.05) increasc in this grolrp w'hcn conrpared rvithtlrat of control groLrp and reacire d2.49 * l.l2 in irrf'ertile 'onren rvith PCO. il{ean value of serunlprogesterone level rvas significantly decreased in thosc rvontel"r and declined to 0.14 ng/L *0.214.Regarding tire age of rvonren, most cases oIPCOS r.i'erc at age grolrps 20-29 and 30-39 years lvhichcorrrprisecl 44.87 % of the 156 cases. | ||
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