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Correlation Betveen Erythromycin- Resistance Phenotypes ofStreptoco cc us Pne unrc nifi e ancl the Invitro Activitl' of Telith romycineand Azithrornycine | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 3, Issue 2, 2007, Pages 127-134 | ||
| Author | ||
| Nuha Saleem Mohammed AIi | ||
| Abstract | ||
| Tow principal mechanisms have so far been found to be responsible for acquirednracrolide ,lincosamide and streptogramin B (MLSB) antibiotics resistance in Streptoioccuspneumoniae : :target site modification and active drr.rg efflux .the target site moclification is due tomethylase ,prevents the binding of the antibiotic to its ribosomal target and can be expressed eitherin a constittttive (cMLS phenotype) or inducible (iMLS phenotype ) manner .the malrolide effluxsystem,M phenotype ,is mediated by a membrane protein responsible for the efllLrx resistance.Although the incidence of resistance to macrolides rvas low in the past,today t5c- ilciclence reportedby several countries shorvs a sensibie increase. Thus it is necessary to search and test novelantimicrobial agents characterizecl by a spectrum of activity against the most collnton respiratorypatlrogerrs. This study conrpared the invitro activity (MIC and MBC) of telithroprl,cin f ith activityof azithromycin against Streptococcus pneumonictc recently isolatecl liom sap (lioyanni BattistaI-tospital (Ttrrin,ltaly). Erythromycin - resistance phenotypes w'ere cleternrinccl thro996 a triple - disk test to correlate a potential diflerent bacterial pattenr to antinricrobial rr'r..ptibility. Theincidencc of er1'thronrycin-resistflltce was 26.66%.ln the groLrp of Ery-li Streptogot'c.tr.s pneumonicte58'33% strains belonged to cMLS phenotype, 33.33% to M phenotype ancl 8.3j% to iMLSphenotype. Telithromycin preseuted MIC values lo*'er tfian those cletecteA fith azithromycinagainst all isolated straius Telithromycin appearecl to be highly active against Streptococcttsltttcumonictc, in particttlar r.vhen resistance is nrediated by the efflgx slstem cop[irptipg its clilicale ff rcacy antong respi ratory streptococcal in fections. | ||
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