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Measurement of CD4 and CD8 in Cutaneous Leishmanisis Patientsand their Relation tvith Zn Deficiency | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 3, Issue 2, 2007, Pages 112-116 | ||
| Authors | ||
| Abed A. Salman and Azad Kamal; Ashoor R. Sarhat; Hussein S. Aswed Al-Obaidi | ||
| Abstract | ||
| tun.ou, leishmainasis still is a common skin infection worldrvide and because it'stype and of clinical course depends on patient's immune system lvhich in tum affected by zinc. Toori*r, the relation of serum zinc, CD4*, and CD8* rvith the disease. A total of 107 patients with CLrvere studied dr.rring period between October/2004-April/2005 in the dermatology department of A1-Harveja general hospital. Patients rvere divided in to tlvo groups according to immune systenldevelopment and Zniequirement. Sixty healthy individuals rvere used as control group, and dividedinto two grollps, first gror-rps 20 individuals'ages rar-rging from l-15 years and second grotlps abovel5 years iheir-ages runging from l6 to 60 years and sub-divided into 20 males and 20 fernales' Afterhistory and examination confimation of diagnosis made by skin snrears. Serum zinc level and CD4*anct iDB* rvere done for all patients ancl control. The nrean of serum Zn concentration in patientsabovc 15 years of age rvas signifrcantly lorv 7.61 + 0.03 ptnrol / I lor male, and 6.69* 0.31 forfenrale irr comparison to 14.08 + 0.04 prmol/l for male, and 12.02 t 0.02 for female in sirnilarcontrol grollp. The mean percent of CD4* in patients above 15 years of age rias signihcantly low36.5 r i.gg" for male, ona :O.Zg t 0.06 o/o for female in comparison to 59.95 * 0.16%% for male,arrd 58.9*0 .14 % for female in similar control group. The mean percent of CD8* in patients above15 years of age rvas significantly loyv 22.37L0.05% for male, ttnd 22.47x0.04% for female inconiparison to 30.95*0.l2o/o for male, and 3l.l5t0.15Yo for female in similar coutrol group. TheCD4*/CD8o ratio mean in patients above 15 years of age r,r'as signifiiantly lorv 1.63+0.004 for ntale'aud 1.6+0.0021 lor female in conrparison to i.g++O.Ot for male, and 1.89*0.011or lentale in similarcontrol group. All patients r.vith iL ilou. zinc deficiency, and have decreasecl in CD'+', CD8*, andclecreased CD4*/CD8* T lyn-rphocytes. | ||
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