Serum immunoglobulin levels in children with acute bacterialmeningitis

Mus,; M, Ab; Khalaf,

	Serum immunoglobulin levels in children with acute bacterialmeningitis
Tikret Journal of Pharmaceutical Sciences
Article 1, Volume 5, Issue 1, 2009, Pages 57-61
Authors
; ab M;
Abstract
To assess serum level of immunoglobulins (IgG, IgA, IgM) in children with acutebacterial meningitis before therapy and at the end of intensive antibiotic therapy and ineoinFarison to Eeairiiy Age eiid=€f;iliEidhdd Lisfitf6ls, *tii {f 3? sanee irilititteil tu lbii;Al=Atheer pediatric hospital (Mosul city) between January 2005 and July 20A7, 29 casesproved to be a case of Haemophilus !-nfluenzae meningitis. Two died during the follow upperiod and 27 cornpleted the study, Also included 30 apparently healthy age and sexmatched subjects taken as control group. Initially from both group (patients and control)5ml venous blood samples were taken and assay of serum immunoglobulin (IgG, IgA,IgM) were done by single radial immunodiftirsion method using commercial kits. Aftertwo weeks of intensive antibiotic therapy another blood samples were taken from thepatients and assay of serum immunoglobulin levels were done using the same method andthe same cornmercial kits. Initially before therapy there was a significant reduction in ailimmunoglobulin levels (IgG, IgA, IgM) in children with acute bacterial meningitis incomparison to controls. After 2 weeks of intensive antibiotic therapy, there was nosignificant difference in the mean serum immunoglobulin levels between the patients andcontrols. Acute bacterial meningitis as a disease and the intensive antibiotic therapy doaffect the humoral immune response as reflected by the serum immunoglobulin levels(IgG,IgA,IgM).

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