The role of some antioxidents in treatment of adultbronchial asthma

Khalaf Awath, Ibrahim; Sharif Abdullah, Mohamed; S. Ahmed, Salam

	The role of some antioxidents in treatment of adultbronchial asthma
Tikret Journal of Pharmaceutical Sciences
Article 1, Volume 5, Issue 1, 2009, Pages 67-75
Authors
Ibrahim Khalaf Awath; Mohamed Sharif Abdullah; Salam S. Ahmed
Abstract
This study has been performed to evaluate the role of antioxidants in the treatment ofbronchial asthma in adult patients. The specific objectives of this study are to evaluatethe therapeutic effect of antioxidants in the treatment of branchial asthma in adultpatients and whether the proper supplementation of antioxidants decreases theexacerbation of asthmatic attack. This study was conducted during the period fromFebruary through December 2008. Eighty asthmatic patients were included in thisstudy. The patients were classified into 2 groups; first group was treated with vitaminE (tablet of 400 units per day) for 2 months duration, and those include 40 patients(24 males and l6 females), they have been subdivided according to the severity intomild asthma (28 patients) and moderate asthma (12 patients), while the other group ofpatients was treated with vitamin E (tablet of 400 units per day) and selenium (tablet100 pg two times daily after meal) for 2 rnonths, and those include 40 patients (27males and 13 females), and they have been subdivided according to the severity intomild asthma (29 patients) and moderate asthma (11 patients). The results revealed asignificant inerease in peak expiratory flow rate (560.25 liter/min)after treatment withvitamin E, than before treatment with vitamin E(524.5 liter/min), while a highlysignificant decrease in serum rnalclndialdehyde was recorded after treatment withvitamin E(2.98 nmollml) than before treatment with vitamin E (3.85 nmol/ml). Therewas significant increase in peak expiratory flow rate after treatment with vitamin Eand selenium (567,25 liter/min) than before treatment (558.0 liter/rnin), serumrnalondialdehyde shows a highly significant decrease after treatment with vitamin Eand selenium (1.60 nmol/ml) than befcrre treatment (3.67 nmollml). The results alsoreveals a clinical improvement in those patients who received vitamin E andseleniurn, because vitamin E and selenium are a better antioxidant than vitamin Ealone, and this proved by a lower serum malondialdehyde level in patients who hadbeen received vitamin E and selenium.

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