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Formulation and Evaluation of Diazepam as a Rectal Preparation | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 2, Issue 2, 2006, Pages 94-103 | ||
| Author | ||
| Ali Ahmed Yas | ||
| Abstract | ||
| Diazepam has become a commonly used drug for treatment of acute repetitive epileptic seizuresand febrile convulsions in children. Considering the advantages of rectal administration ofdiazepam, the objective of this study was to formulate and evaluate rectal hydrogels containingdiazepam as a drug substance in combination with suitable co - solvents and preservatives.PreparedHPMC (hydroxypropyl methylcellulose) hydrogels containing different concentrations of diazepam(2, 4 and 6 mg I ml) manifested good quality in respect to physicochemical parameters (pH value,drug content, ingredients content and viscosity), antimicrobial efficiency and microbiologicalquality. Under the proposed HPLC conditions, satisfactory separation of diazepam and thepreservatives used was achieved. In vitro release studies have shown that the total amount ofdiazepam was released in a period of 3 hours. Prepared formulations were stable for four months at26 C (ambient temperature characteristic of the second climate zone | ||
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