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The role of selective serotonin re-uptake inhibitors in themanagement of premature ejaculation | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 4, Issue 2, 2008, Pages 88-94 | ||
| Author | ||
| Yasir I. Abass Al-Janabi | ||
| Abstract | ||
| A prospective, randomized, placebo-conlrolled study was designed to investigate the efticacy andside effects of the selective serotonin re-uptake inhibitor, fluoxetine hydrochloride, on postponingejaculation in patients with premature ejaculation (PE). A total of 55 men with PE were scheduledto begin this study, but 5 of them have been dropped out for unknown reason, so tbc study wascompleted with a total number of 50 patients. The ages of these patients (who experienced primarypremature ejaculation (lifelong rapid ejaculation)) ranging between 19 to 65 years. The patientswere asked to detennine the time in seconds between vaginal penet.ration and ejaculation (latencytime), by using a clock for four weeks before starting the trcatment,and a baseline meanejaculatory latency time was measured. Then the patients were given either flouxetinehydrochloride or placebo for aditiomal 8 weeks. All patients were interviewed before and 8 weeksafter beginning the treatment.Baseline mean ejaculatory latency time was 60.6 s; 20 mg/day oflluoxetine increased it to 199.3 s, while in patient using placebo it was 68. 15 s (p < 0.001). Thisresulted in significantly greater sexual satisfaction for men: 73% (p < 0.001). Generally. fluoxetinewas well tolerated and there were no major side effects. None of the patients discontinued thempydue to adverse effects. Fluoxetinae hydrochloride may be regarded as a safe and effective option inthe treatment of premature ejaculation. | ||
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