Effect of phenolic compounds Extraction of Green tea (Camellia sinsis. L) On the Glutathione of Alloxan Experimental InducedDiabeticRabbit.

Riffat Sarhat, Entedhar

	Effect of phenolic compounds Extraction of Green tea (Camellia sinsis. L) On the Glutathione of Alloxan Experimental InducedDiabeticRabbit.
Tikret Journal of Pharmaceutical Sciences
Article 1, Volume 4, Issue 2, 2008, Pages 117-125
Author
Entedhar Riffat Sarhat
Abstract
Diabetes Mellitus ;, considered u; a member of oxtdutie stress syndrome. It isns><>lllis stud> showed the effect of the polyphcnol compound~ extracted from green teu(Camellia Sinesis L.) on alloxan induced diabetic l"dbbils to detennine their role intreaunent of diabete> mellitus. their effect on enzymatic antioxidant and to kno" thehistological effects on the diabetic kidney. The rabbits group was divided into fhegroups. each group consist of I 0 rabbits. The blood and thsue samples from thesearoups "e"' taken for anal) si< and the result ere a, follo"':There was a $ignificanrincrease in Glucose "hen pol)p/lenol extract of green tea.,., used ga~ a significantdc"eig1.200mg/kg of bod) "eight as compared "it~ din betic group. There was asignificant decrease in glutathione. When polyphenul extract of green tea wa!> usedwith do~c rate 100mg /kg of bod) weight ga'e a signit1cnnt increase (p<0.05) in allparameters a.~ compared with diabetic group. In comparison between the efficacy ofherbs polyphenol compound in gt·cen tea, glibcneclamide ,it was appeared that theherbs are the bener based on crficacy on treatment of diabetes and their effect onglucose and glutathione. fhe present results revealed that alloxan "'as effectivelyinduced diabetes b} partial de,truction of 1>-cells of pancreas "hich lead to elevationof blood glucose lc•1:l. A• a consequence of h)pel'@lycemia the abnonnal effect 8tigattOJ> sho"s that all the lesions in the kidney that result fromdiJbUch as h)pertroph), degeneration and h}lano,is of the glomeruli.

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