Evaluation of serum ceruloplasmin, copper, iron and Vit.C levels inWomen using oral contraceptive pills in Tikrit city

A.Abed, Saifaldin; R.Mahmood, Ayhan; Riffat Sarhat, Entedhar

	Evaluation of serum ceruloplasmin, copper, iron and Vit.C levels inWomen using oral contraceptive pills in Tikrit city
Tikret Journal of Pharmaceutical Sciences
Article 1, Volume 4, Issue 2, 2008, Pages 140-146
Authors
Saifaldin A.Abed; Ayhan R.Mahmood; Entedhar Riffat Sarhat
Abstract
Oral contraceptive steroids are used by an estimated 60 to 70 million women worldwide.Over the past 20 years there have been both case reports and clinical studies onthe topic of drug interactions with these agents. The use of oral contraceptives hasbeen consistently associated with decreased levels of the activity of many enzymes,and Vitamin C. The main transporter of copper, a2-globulin ceruloplasmin which is amultifunctional enzyme. The present study was conducted in Family planning inTikrit Teaching Hospital in Tikrit province, Serum ceruloplasmin, copper, vitamin C,and iron levels were estimated in 54 women who were using oral contraceptives for atleast I year. The mean age of women was (32.08 years vs. 27.04 years of control). Theserum level of ceruloplasmin (Cp) as antioxidant protein was significantly high incomparison to control group (mean 40.5 mg/dl vs. 33.28 mg/dl, Pof serum copper in women were using contraceptive (17.03 J.!MIL) is significantlyhigher (Pvitamin C values in women using contraceptives were significantly lower than controlgroup (P<0.05), the mean of vitamin C value was 3.452 ~-tM/L vs. 6.534 ~-tM/L ofcontrol. The mean value of serum iron in women were using contraception (8.642~tM/L) which is less significantly (P(17.603 ~-tM/L).

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