Evaluation of serum lipid in diabetic patients on differenttypes of treatment

Aldeen S. Saeed, Hosam; S. Mohammed, Taha; E. Kasem, Samit

	Evaluation of serum lipid in diabetic patients on differenttypes of treatment
Tikret Journal of Pharmaceutical Sciences
Article 1, Volume 2, Issue 1, 2006, Pages 19-25
Authors
Hosam aldeen S. Saeed; Taha S. Mohammed; Samit E. Kasem
Abstract
Diabetes mellitus is chronic metabolic disorder which causes many complications. These are subdivided intomicrovascular complication affecting retina, kidney and peripheral nerves and macrovascular complications(atherosclerosis) affecting the major arterial systems including coronary arteries. Abnormal lipid metabolism iscommon in DM and it play an important role in the macrovascular complications. In this case control study150 diabetic patients on different regimens of treatment were investigated for hyperlipidemia and compared toeach other and to 50 apparently healthy control.Comparison of each group of diabetic patients with the control group was as follow; regarding total cholesterolthere was no significant difference, higlyceride was significantly higher in group 2 (mixed insulin and oralhypoglycemic therapy), and group 3 (oral hypoglycemic drugs therapy) (P<0.001) in comparison with controlgroup, while in group I (only insulin therapy) it was lower than the control group, but the difference wassiatistically not significant, HDL was significantly lower in all groups in comparison with control group and theleast value of HDL was found in group 3 (P<0.001). Regarding LDL there was no significant difference incomparison with the control group, while VLDL was higher in group 2 and 3 than the control group and thedifference was significant (P<0.001). Comparison of the measured parameters among three groups of diabeticpatients was as follow; regarding total cholesterol and LDL there was no significant difference among these threegroups. Triglycerides and VLDL were significantly lower in group 1 (P<0.001), while HDL was significantlylower in group 3 (P< 0.001). Cholesterol, triglycerides and VLDL were significantly higher in females in group 2(P<0.05). Regarding HDL and LDL no significant difference was found between males and females. In group Itriglyceride was higher in those with 5 - l0 years treatment, while in group 2 & 3 there was no significantdifference in measured parameters regarding the duration of treatment.

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