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Evaluation of The Effects ofAmlodipine Therapy on Blood Pressure and KidneyFunction among Hypertensive Patients in Mosul City. | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 2, Issue 1, 2006, Pages 9-14 | ||
| Authors | ||
| Isam llamo Mahmood; Zeina Abdul Mrudm Abdul Majeed | ||
| Abstract | ||
| The present snrdy was mnducted to evaluate fte effect of amlodipine on blmd p€ssurc and kidney function inpatients in Mosul clb,. Thirty patients participated in ftis S.rdy ( 14 female ard 16 nrale )Arnlodipine was administercd for a period of 8 weeks in doses of 5 to l0 mg once daily. Antlripentensive efficacy wasassesd by measurement of blood pressure by standand mercury sphygmomanometer before and afur rcdnent . Bloodsampleswercobtained fiomeachpatientbeforeardafurteatnentand tlreobtainedserawereanalpodforruralpaarnetasvririch they all measr"ned in serum by using mlorimetic and en4anaic mehod. Credinine cleararce was calculded bywingthe Cockoft and Gault ecluation.The resulb of the study showd that anlodipine drerqpy lead tl a sigrificant reduction in blood pressue tllrugfrout thestudy and about 5fflo ofthe patien8 exhibit BP reduction tc notmal values afur drerapy. CreAinine clearance was significarflyincreased afur the end of the sudy . All other renal parameten including urea , credinine, sodilnn and potassiumconcentdions showed a sigrificant reductions. It was concluded that therapy with arnlodipine car be useful ard effediveflrcmpyinhpefiensivepaientswith deterioratdkidneysfi.lictionin oncedailydosage. | ||
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