Induction of brain lesions experimentally by inoculation ofStaphylococcus aureus subcutaneously in rabbits(A histological study)

Zainab,; N.Al-Saadi,; H.I,; Ayad,

	Induction of brain lesions experimentally by inoculation ofStaphylococcus aureus subcutaneously in rabbits(A histological study)
Tikret Journal of Pharmaceutical Sciences
Article 1, Volume 1, Issue 2, 2005, Pages 23-27
Authors
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Abstract
Six aduit rabbits of both sexes were used tostudy the effect of Staphylococcusaureus on lhebrain tissue. Animals were classified into two groups. Group(A) was thecontrol and Group(B) was the treated. Group (A) was inoculated with 0.8m1 salinesolution subcutaneously, and group (B) was inoculaied subcutaneously with 0.8m1suspension of ,S/aph.aureus .The inculation process was tepeated again with group (B)after 15 day. After (15) days from the second inoculation, the all animals of bothgroups were sacrified. A brain specimens from the frontel, parietal and temporal lobesof both groups were taken, processed for histological tech-nique, embedded in theparaffin wax, sectioned at (5) pm thickness and stained by the haematoxylin & eosinlor examination by the light microscopy.The brain tissues of group B, demonstrated the histopathological changes of thewhole sites of the brain lobes, included, focal necrosis of the nerve cells,dernyelination of the nerve fibers and gliosis. This effect may reflect the efficacy ofthe bacteria or its toxin or many both on the brain tissues.

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