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Spectrophotometric Determination of Vitamin B1 (ThiaminHydrochloride)In Pharmaceutical Preparation by CouplingReaction with Diazotized Sulfanilic acid | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 1, Issue 2, 2005, Pages 1-8 | ||
| Authors | ||
| Yousif J. Azeez; Rebwar O. Hassan | ||
| Abstract | ||
| A simple, accurate and sensitive spectrophotometric method for the determination ofvitamin B1 (hiamin hydrochloride) in aqueous solution is described. The method isbased on the diazotization of sulfanilic acid followed by coupling with thiaminhydrochloride in the presence of sodium hydroxide to form reddish-brown watersoluble dye that is stable and has maximum absorption at ( )",u*: 490nm ).The molarabsorptivity and sandell sensitivity were 7.74 x103 L.mol-l.cm-r and 0.045pg.cm-lrespectively. The procedure is developed for bulk thiamin hydrochloride and some oftheir pharmaceutical preparalions. The are accurate, precise and comparable to thestandard method (British pharmacopoeia). | ||
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