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Formulation and Stability Studies of Chloramphenicol asOphthalmic Eye Drop | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 6, Issue 1, 2010, Pages 70-77 | ||
| Authors | ||
| Nuha Nasoh Al- Deeb; Fadhil Bander; Faris .T. Abachi | ||
| Abstract | ||
| The chloramphenicol is D+threo (-) 2,2 dichloro-N-'B-hydroxy -o( hydroxyl methyl)-pnitrophenylacetamide , a bacterioststic and highly effective antibacterial against $ (+)and gr (-) ocular pathogenic bacteria causing conjunctivitis or corneal ulcers. Theophthalmic preparations of chloramphenicol'are produced in different formulation due toits lower stability Therefore , the present study introduce the know-how for the, production of cholramphenicol sterile ophthalmic solution. The ophthaimic preparationsof chioramphenicol 0.4o/, are not produced in Syria as well as the actice agent . Therefore, the prepared report produces the know - how for the production and study the stabilityfbr sterile solution. chloramphenicol for ophthalmic solution is a sterile , dry mixture withborax buffer .The active ingredient is chloramphenicol at concentration ( 40mg / m1 )was prepared under aseptic conditions. The fait yellow color ophthalmic solution , clear ,sterile, isotonic with 306 mOsm lKg, the pH measured at6.51. This solution did notcause any eye irritation in rabbits after daily application for four consecutive days .Finaliy, the stability of the prepared chloramphenicol 0.4% eye drops was studied at 4,25 , 40 and 50C' for 90 days in giass amber containers and calculated tl-re expiration dateof the preparation on was approximately two years | ||
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