Effect of hormonal contraceptives on serum ceruloplasmin,copper, and Vit.C levels in Tikrit city

R. Sarhat, Entedhar

	Effect of hormonal contraceptives on serum ceruloplasmin,copper, and Vit.C levels in Tikrit city
Tikret Journal of Pharmaceutical Sciences
Article 1, Volume 6, Issue 1, 2010, Pages 56-62
Author
Entedhar R. Sarhat
Abstract
Oral contraceptive steroids are used by an estimated 60 to 70 million women worldwide.Over the past 20 years there have been both case repofts and clinical studies onthe topic of drug interactions with these agents. The use of oral contraceptives hasbeen consistently associated with decreased levels of the activity of many enzymeqand Vitamin C. The main transporler of copper, u2-globulin ceruloplasmin which is amultifunctional enzyme. The present study was conducted in Family pianning inTikrit Teaching Hospital in Tikrit province, Serum ceruloplasmin, copper, vitamin c,and iron levels were estimated in 40 women who were using oral contraceptives for atleast 1 year and 40 women who were using copper T(lntrauterine contraceptivedevice). The mean age of women was (33.08 years).For1y non- contraceptive usersparticipated in the study as a control group. They were drawn from the samepopulation and matched for age with the contraceptive-users group. The serum levelof ceruloplasmin (Cp) as antioxidant protein was significantly higher in women wereusing oral contraceptive than control group (60+0.16 mg/dl vs. 36.5+0.96 mg/dl,P<0.05) while the difference between the serum (Cp) in control and women uiingcopper T is statically non significant P<0.05, also mean of serum copper in womenwere using contraceptive (18+0.612 pM/L) is significantly higher (P<0.01) than themean of control (11.2+0.474 pMiL), while the difference between the serum copperin control and women r-rsing copper T is statically non significant(p<0.01). On ineother hand the serum vitamin C values in women using oral contraceptives and copperT(5.57+0.02 , 6+0.031 pM/L respectively) were significantly lower than conirolgroup(10.73+ 0.09 pM/L, P<0.05.

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