The relaxant effect of some drugs and aqueousextract of medicinal plants on bionchial smoothmuscle in rabbits

Al, Waseem; Jumaily,; H. Al-Jawad, Faruk

	The relaxant effect of some drugs and aqueousextract of medicinal plants on bionchial smoothmuscle in rabbits
Tikret Journal of Pharmaceutical Sciences
Article 1, Volume 1, Issue 1, 2005, Pages 58-63
Authors
Waseem Al; ; Faruk H. Al-Jawad
Abstract
Histamine is a biogenic amine. that produces bronchospasm when it is used (I V)at.a.dose of 0.4 mg / kg in rabbits. It significantly reduced the ,e- l"u"i. oicalcium (Ca) magnesium (Mg) and selenium (Se). (p < 0.05) .Forty rabbits were involved in this study. The serum ca, Mg and Se levels weremeasured before and after giving histamine and following [e administration oiaqueous extract of medicinal plants Cumi'um cyminum (cumin), Thymus vulgaris(thyme) and Anthemis nobilis (chamomile).^ The serum Ca, Mg and Se levels of were highly elevated after treatment with extract cumin or chamomile in rabbits pretreated with histamine, the resurts of ca werechanged lrom 8.34+ 0.40 and 8.79+ 0,27 to 33.41+ 0.50 and 97.62 ! 7.2 1tg /dlrespectively while that of Mg from 20.20+ 0.37 and 19.47+ 0.31 to 74.97+ 0.ii and89.14+ 1.41 pg /dl where as the serum level of Se was changed from 137.9g+ 0.4gand 145 36 + 0.66 ro 302.69 ! 0.6g and 245.4r,' 0.g1 pg /direspectivery .All theseresults were significant at p<0.05.The aqueous extracts of cumin or chamomile were used orally at a dose of 1.5 gm /kg in rabbits to relieve the bronchospasm and symptoms of dyspnea induced iy histamine. These results indicated crearly the poiuiiity of using these extracts flr patients with chronic asthma after the adjustment ofthe effective dose.

Statistics Article View: 71 PDF Download: 10