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Influences of clarithromycin on the primary functions of human. polymorphnuclear leucocytes againstS t repto co c c us p n e um o ni ae | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 4, Issue 1, 2008, Pages 57-62 | ||
| Authors | ||
| Waseem AliHassan; Nuha Saleem Mohammed Ali | ||
| Abstract | ||
| Current antibiotic therapy encourages the use of antibiotics that may potentiate the host's immunedefense. Antibiotics that can interact positively with the immune response and that also possessmicrobicidal properties might significantly contribute to improving the outcome of St.pnetimoniaeinlections .Therefore, in the present study rve investigated the effect of clarithrornycin,an extendedspectrum macrolide currently used in the treatment of respiratory tract infections ,on the in vitrointeraction bctrveen human polymorphnuclear granulocytes (PMN) and strains of St.pneumoniae withdifferent resistance patterns to penicillin .At a concentration of one -half the minimal inhibitoryconcentration(MlC),clarithromycin, an significantly enhanced human PMN functions particularlyintracclltrlar bactcricidal activity, agninst all thc St,pncumonirrc strains,our findings support the use ofclnritlrrornycin in the trcatmcnt of rcspiratory tract infcctions causcd by St.prtcurnoniac as it acts directlyagainst thc pathogcn as rvcll as in coopcration rvith PMNs by cliciting thcir intraccllular killing. | ||
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