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The Role of Oxybutynin Chloride in the Management of Patientswith Benign Prostatic Hyperplasia | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 4, Issue 1, 2008, Pages 63-68 | ||
| Authors | ||
| Nehad N. Helal; Rabei A. Salih; Mohammed M. Abdul-Azizr | ||
| Abstract | ||
| Objectives: To determine the efficacy and tolerability of Oxybutynin chloride in men with benignprostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) in which previous a-blockertherapy had failed.Materi4ls and Methods: A total of 38 consecutive men with BPH complaining of LUTS in whom amean of 6.3 months of a-blocker therapy had failed received Oxybutynin (S *g twice daily orally) for 3months in addition to the usual c-blocker medication. Primory .ifi.o.y .n-d points wlre AmericanUrological Association symptom score, and mean day'time and nighttime micturition frequency.Secondaryend points were the peak urinary florv rate, post-void residual volurne, the incidence of urinaryretention, and adverse events. Statistical analysis rvas used when needed.Rcsults: A total of 33 men (87%) lvith a mean age of 59 years complctcd the 3-month trial. Mean 24-hour micturition frequency decreascd from ll.2 to 6.5 voids and nocturia decreased from 5.1 to 2.4episodes nightly. Significant cltanges in mcan American Urological Association symptom scores (-5.31), thc peak urittaty florv ratc (1.8 nrl pcr sccond) and post-vofd rcsiclual volumc (-2i ml) were alsoobscrvcd. Fivc nrcn (13%) discontinucd tlrcrapy bccausc of intolerablc clry mouth. Thcrc rvere no reportsof urinary rctcntion.Cottclttsions: Trcattttcttt rvitlt Oxybutynin in carclirlly sclcctccl rncn rvit6 Bpll alcl nroclcratc LUI'S mavbc n rcasottablc thcrapcutic optiorr allcr ftrilcd trcatrncnt rvitlr a-blockcrs. | ||
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