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Identification and study of cultural conditions affecting Neomycinantibiotic produced by Streptomyces sp. N | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 4, Issue 1, 2008, Pages 37-43 | ||
| Authors | ||
| Abd.l Malik W; ; R. S; R. N; | ||
| Abstract | ||
| Cuftural conditions affecting antibiotic production by local isolate of Streptomyces sp. N werestudied. Cultural conditions included groMh medium, growth temperature,pH, and ion effect. The studyshowed that this local isolate was able to produce neomycin antibiotic. This compound showed abiological activity against gram - positive, and gram - negative bacteria. This effect was variabledepending on the factors studied. Media of antibiotic production, R2 medium, and complete mediumrvere better for Slreptomyces growth. Growth of the organism for 5 days gave the largest inhibition zonesagainst test bacteria. The organism shorved better gror,l,th and antibiotic production when cultivated at370C. The pH of the medium showed a dramatic effect on antibiotic production since low pH hadincreased antibiotic release to the medium resulting in observed increased in the biological activity. Ionslike phosplrate and citrate shorved diff'erenteff'ecton the antibiotic production. Tlrc phosphate had shorvnan enltancing effect rvhere as citrate inhibit antibiotic production and lowercd the grolvth of the organismon cultivation media. | ||
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