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Effect of Carbon and Nitrogen sources on the antibioticproduction by local isolate of Streptomyce s sp.Zl | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 4, Issue 1, 2008, Pages 19-28 | ||
| Author | ||
| Ayhan R. Mahmod | ||
| Abstract | ||
| The genus Streptomyces consists of sporulating Gram-positivesoil bacteria with a mycelia growthhabit, and a life cycle with complex morphological and physiological differentiation, also piodu..,antibiotics which are the secondary metabolite.The objective of the present study is to study of an ability of a local isolate of Streptomyces Zl toproduce antibacterial substance, and effect of different carbon and nitrogen sources on antibacterialproduction. Results in present study showed that Streptomyces Zl have ability to produce antimicrobialagent against Escherichia coli, Shigella dysentery, Pseudcimonas aeruginosa, Klebsiella pneumoniae,Staphylococcus aureus, Staphylococcus epidermidis, Bacillus nrbtilis which indicated by diameter ofinhibition zone that reached tol6.0, 19.3, 18.1,25.0, g.z, 11.2, l2.o mm, respectively, iesults in thisstudy showed that antimicrobial agent produced by Streptomyces Zl lvas more effective against gramnegative organisms rather tlian gram positive.Production of antibiotics from microorganisms varies with the constituents of the media. In presentstudy we have investigated the influence of medium constituents such as carbon and nitrogen soui.., onthe antibiotic production from Strcplomyces Zl, different carbon sources were used in this studyincludcd the follorving: maltose, glycerol, galactose, glucose, mannitol, lactose, starch, and dextrose, thesamples werc assayed against K. pncumonic, the highest antibacterial activity rvas obtained whendextrose at 4Yo rvas used as carbon sources. We have also tested a numbcr of nitrogen sources (Yeastextract, L-valinc, sodium glutamate, Na2NO3, Nl'l4SO4, Nl-l4NO3) orr antibiotic production by localisolate of Strcptonr),cc:; sp.Zl, rcsults shorvcd that Yeast cxtract at l.SYo was thc most suitable nitrogensollrcc, tlrouglr L-valinc, sodiurn glutarnatc, Na2NOj, NI-l,rSO.r, NI.ITNOJ gavc modcrate antimicrobial | ||
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