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Effects of melatonin and zinc on oxidative stress in poorly controlled type 2 diabetic patients treated with metformin | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 7, Issue 2, 2011, Pages 115-123 | ||
| Abstract | ||
| Background: Glycemic control and prevention of secondary complications are the most important goals of using pharmacologic treatment of diabetes mellitus (DM).The administration of antioxidants such as melatonin and zinc may improve tissue responses to insulin and increase the efficacy of drugs, e.g. metformin, which act through this pathway. This project was designed to evaluate the effects of melatonin and zinc on the oxidative stress status in type 2 DM patients poorly controlled with metformin. Patients and methods: A placebo-controlled, double-blind clinical trial was performed in which 46 type 2 diabetic patients were selected and allocated into three groups. These groups were treated with single daily oral doses of both 10 mg of melatonin and 50 mg of zinc acetate alone: in addition to the regularly used metformin or placebo, given at bedtime for 90 days. Plasma Malondialdehyde (MDA); plasma glutathione (GSH); and plasma zinc and copper levels were measured before initiating the treatments (zero time) and after 30 and 90 days of treatment. Results: Daily administration of melatonin and zinc effectively normalizes the impaired antioxidant status, and significantly elevates serum zinc levels after 30 and 90 days compared to placebo treated group; the addition of this treatment regimen in combination with metformin improved the tissue responses to this oral hypoglycemic agent. Conclusion: the combination of melatonin and zinc acetate, when used alone or in combination with metformin, has a significant decrease in lipid peroxidation and improvement in antioxidant status , and this effect can be related to several mechanisms in type 2 DM patients. | ||
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