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Synthesis and Characterization of New Fused Heterocyclic Compounds Consisting of Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole Rings | ||
| Baghdad Science Journal | ||
| Article 1, Volume 5, Issue 3, 2008, Pages 440-445 | ||
| Authors | ||
| Hanan Abd El-Latif Ibraheem; Nadia Adil Salih | ||
| Abstract | ||
| In this study, new heterocyclic compounds were synthesized through the cyclization reactions of o-phenylenediamine (1) with various organic reagents. Benzodiazepine derivatives (2-4) were obtained by reaction of (1) with ethylacetoacetate, malonic acid and acetyl acetone.Treatment of compound (1) with chloroacetamide, chloroacetic acid, p-bromophenacyl bromide and oxalic acid dihydrate afforded quinoxaline derivatives (5-8), respectively. Reaction of compound (1) with benzoic acid, piperonal, cyclohexanone and carbon disulfide resulted in the formation of compounds (9-12), respectively. Finally, reaction of compound (12) with chloroacetic acid in the presence of potassium hydroxide produced compound (13). | ||
| Keywords | ||
| benzodiazepine; Quinoxaline; Benzimidazole and Thiazole; Cyclization Reactions | ||
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