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Evaluation of transfer factor protective efficacy against Tuberculosis in Guinea Pigs | ||
| The Iraqi Journal of Veterinary Medicine (IJVM) | ||
| Article 13, Volume 29, Issue 2, 2005, Pages 112-121 PDF (0 K) | ||
| Authors | ||
| A.A. AL-Samarrae; ; Khalifa A. Khalifa; R.S. Mohammed; | ||
| Abstract | ||
| Transfer factor has been prepared from sensitized guinea pigs against heat killed Mycobacterium bovis antigen and protective efficacy were evaluated in guinea pigs that gave 1 ml of transfer factor equivalent 5x108 cell / ml of sensitized and normal cell donor; then challenged with dose 0.01 mg / animal of virulent Mycobacterium bovis, After 40 days of challenge all animals were sacrificied. Histologically: - TFs recipient group showed a mono-nuclear cells infiltration’s (Lymphocytes & Macrophages) with a mild emphysema of lungs, and liver showed mononuclear cells ,a small necrotic foci in the lymphocytic organs (spleen & lymph nodes); the kidney showed mononuclear cells in glomeruli and urinary tubules ;While the TFn recipient group were an areas of caseated necrotic materials surrounded by macrophages &Lymphocytes, congestion of internal organs (Liver and Spleen) and Sever congestion with hemorrhage of alveoli tissue, sever emphysema & consolidation in lung kidney showed tuberculle foci in glomeruli and around urinary tubules . There were no pathgenomic changes in heart muscles of TFs recipient group while a mild congestion in TFn recipient group. | ||
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