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EVALUATION OF ANTIMICROBIAL ACTIVITY OF WATERY AND ALCOHOLIC EXTRACTS FOR MATRICARIA CHAMOMILLA ON INHIBITION OF GROWTH OF GRAM POSITIVE PATHOGENIC BACTERIA ISOLATED FROM PHARYNGITIS AND TONSILLITS CASES | ||
| Iraqi Journal of Biotechnology | ||
| Article 1, Volume 6, Issue 1, 2007, Pages 52-70 | ||
| Abstract | ||
| ABSTRACT The effects of Matricaria chamomilla plant extract were studied in respect to their of gram positive bacterial growth inhibition. were isolated from cases of pharyngitis and tonsillitis. alcoholic and hot water extracts of the plants as well as their dried powders were prepared. The preliminary chemical tests revealed acidic pH of all extracts. The dried powder, watery and alcoholic extracts of M. chamomilla contained resins,tannins,couumarines ,phenols, flavonoids and avery little amount of glycosides in its watery extract and dry powder, with a small amount of alkaloids in its alcoholic extract.The alcoholic extract of M. chamomilla showed more patent inhibitory effect on resistant bacteria than its watery extract and the best effect was on growth of Strept.pneumoniae and Strept.pyogenes inhibition zone diameter 27.0 mm. In the present study, the Minimum inhibitory concentration (MIC) and Minimum bacteriocidal concentration (MBC) of the plants extracts were measured for the more predominant gram positive isolates and the results varied according to different kinds of plant extracts and different types of bacteria. The least values of MIC and MBC were for alcoholic extract of M. chamomilla on Streptococcus pyogenes and Streptococcus pneumoniae which valued 20% , 30% respectively. It has been noticed that the watery extracts of M.chamomille, have a sedative effect when given dosing 5 g/kg for laboratory mice , these extracts however, showed a synergistic sedative effect when mixed with pentobarbitone and caused prolongation of sleeping time in experimental mice .Neither the alcoholic nor the watery extracts of the plants showed any toxic effect on the laboratory mice after oral dosing of 2.5 –15 g /Kg B.W. Key word: Watery and alcoholic extracts, Matricaria chamomilla , Pharyngitis ,Tonsillitis. | ||
| Keywords | ||
| Watery and alcoholic extracts; Matricaria chamomilla; Pharyngitis; Tonsillitis | ||
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