THE IMMUNE RESPONSE TO DIPHTHERIA TOXOID IN CHILDREN VACCINATED WITH DPT VACCINE

	THE IMMUNE RESPONSE TO DIPHTHERIA TOXOID IN CHILDREN VACCINATED WITH DPT VACCINE
Iraqi Journal of Biotechnology
Article 1, Volume 6, Issue 2, 2007, Pages 88-99
Abstract
In this study, 64 blood samples were taken from the healthy children after 2-4 weeks of vaccination by DPT. The children were divided into three groups according to the number of the doses of vaccine .The aged of children of the first three groups ranging from 6-55 months while the age of the fourth group ranging from 6-12 years, received the fifth dose of vaccine before 2-8 years. The control group included fifteen healthy children. They were aged between 11-85 months and they had not been received DPT vaccine before. Neutralization test was used to assess the concentration of the diphtheria antitoxin (DAT). The results showed that the serum first three groups of children contain a concentration of DAT higher than 0.1 IU/ml at the percentage 98.4% while the results of the fourth and control groups showed reduce of the DAT concentration less than 0.1 IU/ml at the percentage 60.86% and 100% respectively. Also the result showed an increase in the concentration of DAT as the number of the vaccine doses increased. Where the fifth dose showed significant differences in DAT concentration (p ≤ 0.001, 0.01, 0.05) in comparison with control, the third and the fourth doses respectively. The results showed negative direct correlation between the age of fourth group and the concentration of DAT (r= -0.730) and also there was positive direct correlation between the number of days after the vaccination and the concentration of DAT (r = 0.532) for the first three groups of the vaccinated children.
Keywords
Key Words; Vaccination; DAT; Neutralization test

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