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Biochemical and Haematological Study in Rats Exposed to Cadmium Chloride in Drinking Water | ||
| The Iraqi Journal of Veterinary Medicine (IJVM) | ||
| Article 2, Volume 31, Issue 2, 2007, Pages 15-29 PDF (0 K) | ||
| Authors | ||
| ; Bara N.AL-Ekelly | ||
| Abstract | ||
| The objective of this study was investigate the Physiological effect of different concentrations of cadmium chloride in drinking water on some biochemical and haematological parameters of male rats. Animals in this experiment were randomly divided into four equal groups and treated for 15 weeks as follows : Rats in control group were offered ordinary tap water , while animal in M1 , M2 , and M3 were received 10 , 20 , 30 ppm Cdcl2 in drinking water, respectively. The activity of Alanine aminotransferase (ALP), Aspartate aminotrasferase (AST) and alkaline phosphatase (ALP) in serum were measured. Further mor, hemoglobin concentration (Hb) and white blood cells count (WBCs) were detected. The result revealed that addition of cadmium chloride in different concentrations in drinking water caused a significant increase in activity of serum of ALT in treated group (M1 , M2 , M3 ) as compound with control. Within the time the activity of serum AST was significantly increased in three treated group as compared with pretreatment period. On the other hand , significant increase in serum ALP concentration were show in both M1 and M3 treated groups at 12th and 15th week of the treatment as compared with control group. Significant decrease in haemoglobin concentration were observed in M1 , M2 , M3 from 9th week to the end of experiment comparing to control. While cadmium chloride treatment caused significant increase in total white blood cells count in treated groups as compared with control group. On Conclusion, it seems likely that exposure of male rats to cadmium chloride at level above the permissive one had induced clear biochemical and haematological changes. | ||
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