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The effect of Aloe Vera leaf gel in promoting wound healing and as antibacterial | ||
| The Iraqi Journal of Veterinary Medicine (IJVM) | ||
| Article 5, Volume 32, Issue 2, 2008, Pages 46-59 PDF (0 K) | ||
| Authors | ||
| Ali Aziz Al-Khayyat; Lubna Ahmed Kafi; Zena Munther A | ||
| Abstract | ||
| This study was carried out to explore the effect of Aloe Vera leaf gel in promoting wound healing and to investigate the antibacterial effect against some pathogenic bacteria in comparison with Nigella sativa oil. Standard dilutions of Aloe Vera leaf gel were made from ten to one hundred percent and its antibacterial effect had been examined in seeded agar method against Staphylococcus aureus and Pseudomonas aeruginosa both were previously identified by laboratory and biochemical methods, Nigella Sativa oil which is known to be one of the important medicinal plant was used for comparison . Statistical analysis showed a significant difference (P<0.05) between AVG and Nigella Sativa oil. The effect of Aloe Vera leaf gel against Staph .aureus was more potent than against Pseudomonas aeruginosa. There was a proportional relation between different concentrations of AVG with the values of inhibition zones diameters of the bacteria. Results showed that Aloe Vera was more potent than Nigella sativa against both bacteria. The Minimum Inhibitory Concentration (MIC) was sixty mg/ml and the Minimum Bactericidal Concentration (MBC) was eighty mg/ml for Staph .aureus. In order to investigate the effect of Aloe Vera gel on wound healing, twenty-four local male rabbits were used. They were divided into four equal groups and each animal was wounded in both sides of the back region by making a one by two centimeter square standard longitudinal incision with surgical scalpel. The first group was a control group (wounded without treatment); this group was employed to observe the normal wound healing. The second group was treated with crude Aloe Vera leaf gel twice daily for 10 days. While the third group was wounded and infected with the pathogenic bacteria Staphylococcus vaureus without treatment, in order to observe the natural body defense against pathogenic microorganisms. The last group was infected with the same bacteria but treated with crude Aloe Vera leaf gel to observe the antibacterial effect. The wounds in the left side in second and fourth group were left as self-control. The treated groups were compared with the control group and the self-control in respect to period of healing and feature through visual observation of changes. Furthermore, in order to assess the effect of topical Aloe Vera gel in promoting wound healing, twelve adult male mice used; they were divided into two equal groups. A hole was induced in each animal by a biopsy needle; the control group received no treatment while the other group was receiving topical treatment with crude Aloe Vera gel twice daily for ten days. A significant decrease in wound diameter was noticed in the animals treated with Aloe Vera gel in comparison with the non-treated control group. From the above-mentioned results, it can be concluded that this study is a good step to show that crude Aloe Vera leaf gel promotes wound healing and has an antibacterial effect in vitro and in vivo against Staphylococcus aureus and Pseudomonas aeruginosa. | ||
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