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Role of Omeprazole as An Antifungal Agent | ||
| Engineering and Technology Journal | ||
| Article 1, Volume 29, Issue 2, 2011, Pages 336-340 PDF (143.94 K) | ||
| DOI: 10.30684/etj.29.2.13 | ||
| Authors | ||
| Omar A. Al-Mukhtar; Suhad A. Ahmad; Raya R. Jabri; Ali A. Juwaied | ||
| Abstract | ||
| The antifungal activity of various concentrations of omeprazole (0.1mg/ml, 0.25mg/ml, 0.5mg/ml, 1mg/ml, 2.5mg/ml, 5mg/ml, 10mg/ml, and 20mg/ml) were studied in different pH media (5 and 7) against Aspergillus niger, and Trichophyton urbrum.The laboratory results showed the inhibitory effect of omeprazole against Aspergillus niger at pH 7 and starting from concentration 10mg/ml, and against Trichophyton urbrum starting from 1mg/ml. While its antifungal activity in a medium with pH 5 was extended to reach the lower concentrations 0.25mg/ml against selected fungi. Accordingly, omeprazole is pH dependent.It seems that omeprazole changed cell membrane potential of selected fungal species which led to depolarization of cell membrane as a result of inhibition of the proton pump mechanism. This made the fungal cell not willing to uptake chemicals needed for living.Keywords: omeprazole, proton pump inhibitor, antifungal agent, Aspergillus niger, and Trichophyton urbrum. | ||
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