EFFECT OF LONG TERM ADMINISTRATION OF ROCKET (Eruca sativa) ON SOME CYTOGENETIC PARAMETERS IN WHITE MICE

A. Khalaf, Ilham

doi:10.33899/magrj.2009.27382

	EFFECT OF LONG TERM ADMINISTRATION OF ROCKET (Eruca sativa) ON SOME CYTOGENETIC PARAMETERS IN WHITE MICE
Mesopotamia Journal of Agriculture
Article 18, Volume 37, Issue 1, 2009, Pages 131-139 PDF (0 K)
DOI: 10.33899/magrj.2009.27382
Author
Ilham A. Khalaf
Abstract
The effect of long administration of rocket (J) alternatively with cyclophosphamide (Cp) on some cytogenetic parameters in white mice bone marrow cells was studied , these inlcluded mitotic index (MI) , micronuclei (Mn) formation , and chromosomal aberrations (Ch. ab.) . In addition the effect was studied on germ cell (Sperms) by scoring the number of sperm-head abnormalities and type of abnormalities . Results indicated that Cp reduced the MI by 55 % of the normal value (6.84) , while treatment of rocket with the drug (J+Cp) restored 85.5 % (5.85) of the normal value , followed by (Cp/J) restored 83.3 % (5.7) and the treatment (J/Cp) restored the lowest level 71.5 % (4.89) . Cp raised the Mn to 18.16 which is (17) times the natural value , administration of rocket with the drug simultaneously reduced the number to 6.02 , the best treatment was (Cp/J) as the number lowered to (5.860 , then the treatment J/Cp (6.76) , all of them were higher than the negative control with significant difference (P<0.01) . Cp increased the number of Ch. ab. To about 10.5 times the natural value (1.62) , but the different treatments lowered the aberrations with significant differences compared to the positive control (P<0.01) , and the best was (J+Cp) treatment as the number reduced to 3.25 . Cp increased the number of abnormal sperms to about (18) times the natural baseline (1.15) , different treatments (mentioned above ) were able to reduce the sperm-head abnormalities to levels differ from the positive control significantly (P<0.01) . The best treatment was giving the animals rocket and drug simultaneously , as the number lowered to 3.98 , followed by Cp/J treatment (6.65) , then J/Cp treatment (7.21) , all those were higher than the negative control with significant differences (P<0.01) , the types of abnormalities were affected similarly .

Statistics Article View: 399 PDF Download: 183