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EFFECT OF LONG TERM ADMINISTRATION OF CARROT ROOTS (Daucus carota) ON SOME CYTOGENETIC PARAMETERS IN WHITE MICE | ||
| Mesopotamia Journal of Agriculture | ||
| Article 18, Volume 37, Issue 3, 2009, Pages 137-146 PDF (0 K) | ||
| DOI: 10.33899/magrj.2009.27435 | ||
| Author | ||
| Ilham A. Khalaf | ||
| Abstract | ||
| The effect of long term administration of carrot roots (2 months) on some cytogenetic parameters in bone marrow cells of white mice was studied , these included , mitotic index (MI) , micronuclei formation (Mn ) , and chromosomal aberrations (Ch . ab .) of different types . In addition the effect was studied in germ cells (Sperms) by scoring the number and types of sperm – head abnormalities in comparison of the effect induced by cyclophosphamide (Cp) . Results showed that Cp reduced the MI to about 44 % of the normal value (6.84), administration of carrot before the drug (Ca/Cp) raised the index to 74 % of the normal value , while administration of carrot with the drug (Ca+Cp) restored 92.4 % , and administration of Cp followed by carrot (Cp/Ca) restored 88.9 % of the normal value . Cp induced Mn to about 17 times of the baseline value 1.06 .The different treatments with carrot reduced the Mn to 3.8 – 6.7 times the natural values , and the (Ca/Cp ) treatment was the best . Cp treatment for long time raised the Ch .ab. to about 10 times the natural value 1.62 , these values reduced upon administration of carrot to about 24.5 – 29.8 % of the positive control 17 , and such effect extended to the types of Ch. ab. except that of dicentric chromosomes which persisted with high values , but it was lower than the positive control with statistical difference (P<0.01) . The drug increased the sperm – head abnormalities to about 18 times the natural background 1.15 . Different treatments of carrot reduced the level of abnormalities with significant differences compared to positive control (P<0.01) , but the abnormalities were higher than the negative control with statistical difference (P<0.01) , these results were reflected on the types of abnormalities . | ||
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