ANTIOXIDANT STATUS IN THALASSEMIC PATIENTS

AL-Duliami, Najat; J. Musa, Raad; S. AL-Mudalal, Subuh

	ANTIOXIDANT STATUS IN THALASSEMIC PATIENTS
IRAQI JOURNAL OF MEDICAL SCIENCES
Article 1, Volume 4, Issue 1, 2005, Pages 38-44
Authors
Najat AL-Duliami; Raad J. Musa; Subuh S. AL-Mudalal
Abstract
Background: increased membrane lipid peroxidation in patients with thalassemia has been reported suggesting that superoxide radicals generated in excess following auto-oxidation of isolated hemoglobin chains is an important contributor to the hemolytic process. Objective: This study was undertaken to evaluate the extent of lipid peroxidation and antioxidant status of patients with beta-thalassemia in comparison to healthy people. Methods: Red cell superoxide dismutase (SOD) activity and red cell catalase activity were measured in the biochemistry department for the period from January 2003 to October 2003, 76 patients with beta-thalassemia, 14 patients with beta-thalassemia minor and 19 healthy controls were studied. Results: Erythrocytes of patients with beta-thalassemia major had significantly higher SOD than control (p<0.0004). Red cell catalase activity of thalassemia minor patients was significantly higher than that of the control (p<0.05). In thalassemic patients, the more anemic patients have significantly higher SOD activity, but this correlation was not present between anaemic patients & catalase activity. Conclusion: Red cell superoxide dismutase activity was greatly increased in homozygous beta-thalassemia, and inversely correlated with severity of anaemia. Keyword: SOD, Catalase, Thalassemia
Keywords
SOD; catalase; Thalassemia

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