VASCULARIZATION IN PROSTATIC CARCINOMA

A. Al-Rawi, Faiza

	VASCULARIZATION IN PROSTATIC CARCINOMA
IRAQI JOURNAL OF MEDICAL SCIENCES
Article 1, Volume 4, Issue 1, 2005, Pages 45-48
Author
Faiza A. Al-Rawi
Abstract
Background: Angiogenesis means the creation of new blood vessels, a critical natural process that occurs in the body both in health and in disease. Objective: Quantitative assessment of tumor vascularization in different grades of prostatic tumors. Methods: 23 paraffin blocks of prostatic biopsies (8 cases of benign prostatic hyperplasia and 15 cases of protatic carcinoma equally distributed in well, moderately and poorly differentiated (Gleason’s grade 2, 3 and 4&5 respectively). Processed routinely and stained with hematoxylin and eosin, elastica Van Gieson, and Masson Trichrome stain. The vascular surface density (VSD), the microvessels number (NVES), and the maximum microvessels number (NVES-MAX) was assessed by means of stereology, and the results were related to grade of tumor differentiation. Results: NVES and NVES-MAX showed a significant increase with rising tumor grade ranging from 16.1 in BPH to 109.0 microvessels/mm2 in poorly differentiated (grade 4&5) tumors. Discrimination of different tumor grades was more accurate with NVES-MAX. The VSD was significantly higher in low-grade tumors compared with BPH, whereas there was continuous decrease from low grade (11.6mm-1) to high-grade tumor areas (5.1 mm-1). Conclusions: The present study shows a correlation between tumor grade and vascularization. Key words: Prostate cancer, angiogenesis, vascularization.
Keywords
Prostate cancer; angiogenesis; vascularization

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