EFFECT OF GARDEN CRESS (LEPIDIUM SATIVUM ) ON MITOTIC INDEX AND FORMATION OF MICRONUCLEI IN WHITE MICE BONE MARROW CELLS

A. Khalaf, Ilham

doi:10.33899/magrj.2010.27887

	EFFECT OF GARDEN CRESS (LEPIDIUM SATIVUM ) ON MITOTIC INDEX AND FORMATION OF MICRONUCLEI IN WHITE MICE BONE MARROW CELLS
Mesopotamia Journal of Agriculture
Article 17, Volume 38, Issue 3, 2010, Pages 128-136 PDF (0 K)
DOI: 10.33899/magrj.2010.27887
Author
Ilham A. Khalaf
Abstract
The effect of garden cress ( Lepidium sativum ) on mitotic index (MI) and formation of micronuclei (Mn) in bone marrow cells of white mice was studied , in addition to the study of the counter effect of plant juice on MI disruption and Mn induction by cyclophosphamide (Cp) . The results indicated that Cp reduced the MI to level of positive control after 2 , 4 , 6 days with significant differences compared to the negative control (P<0.01) , while the plant juice 0.1 , 0.25 , 0.5 ml / animal administrated orally had no effect and the MI values were similar to the negative control. Oral administration of juice before administration of the mutagen (R/Cp) or with the mutagen (R+Cp) helped the tissues to preserve their MI values at natural level. Administration of juice after the mutagen (Cp/R) resulted in reduction of MI values compared to the natural values with statistical significant difference (P<0.01) Results of Mn induction indicated that the quantities of juice used had no effect on induction of Mn and were significantly different from positive control . Similar results obtained upon using the treatment (R/Cp), but using the juice with mutagen (R+Cp) or using the juice after mutagen (Cp/R) elevated the count of Mn with significant differences (P<0.01) and the case persisted for 6 days (the experiment duration ) .

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