- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
A RANDOMIZED PROSPECTIVE STUDY COMPARING THE EFFECTIVENESS OF MITOMYCIN C AND MITOMYCIN/S2 COMPLEX SEQUENTIAL INTRAVESICAL THERAPY FOR SUPERFICIAL BLADDER CANCER | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 4, Issue 1, 2005, Pages 72-76 | ||
| Authors | ||
| Mahmood H. Hammash; Abdul-Wahab R. Hamad; Ahmad A. Al-Azawi | ||
| Abstract | ||
| Objective: Comparison of two protocols regarding efficacy and toxicity of intravesical mitomycin C versus mitomycin C and S2 complex sequential therapy for superficial transitional carcinoma of urinary bladder. Methods: A prospective, randomized parallel two lines of treatment groups. Seventy-three patients were evaluated after transurethral resection of superficial bladder cancer with median follow-up of 26 months. In group A, 37 patients received intravesical mitomycin C 30mg on day1 weekly for 6 weak and monthly for 12 month, while group B (36 patient) received in addition to mitomycin C, intravesical S2 complex 3ml on day 2. Statistical analysis performed by Kaplan-Meier methods. Result: After follow-up of 26 months, 46% of patient given mitomycin C were disease free compared to 70% for that of group B patient who received mitomycin C and S2 complex, with no significant difference in incidence of the adverse effects. Conclusion: The results show that intensive intravesical instillation of sequential mitomycin C and S2 complex; were highly effective in eradication and/or prophylaxis of superficial transitional bladder cancer. Key ward: Transurethral resection; bacillus Calmitte-Guerin; complete response; mitomycin C, carcinoma in situ | ||
| Keywords | ||
| Transurethral resection; bacillus Calmitte; Guerin; complete response; mitomycin C; carcinoma in situ | ||
|
Statistics Article View: 168 PDF Download: 57 |
||