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ROLE OF TOTAL AND LIPID -BOUND SIALIC ACID IN DISCRIMINATIG ACTIVITES OF RHEUMTOID ARTHRIRIS PATIENTS | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 4, Issue 2, 2005, Pages 134-140 | ||
| Authors | ||
| Alaa K.Mohammed; Yahya Y.Z.Farid; Israa S.Mohammed | ||
| Abstract | ||
| Background: It is known that total serum sialic acid (TSA) and lipid bound sialic acid (LSA) levels may be altered by different types of disease included Rheumatoid Arthritis (RA) and inflammatory disease, therefore the evaluation of these compounds in serum patients with RA may elucidate the relationship between its levels and disease activity. Aim: This study was designed to evaluate the clinical application of serum total sialic acid (TSA) and lipid bound sialic acid (LSA) levels in patients with RA, considering the disease activity and compare the levels with a normal group. Method: The study was carried out on ninety-seven healthy and sick adults. Fifty-four (37 female, 17 male) patients with RA disease. Of them 29 patients (21female, 8 male) had low disease activity [age range 32-65 years] and twenty-five patients (16 female, 9 male) had high disease activity [age range 22-52 years]. They were compared with 43 healthy persons [age range 19-64 years]. Colorimetric methods were used for determination TSA and LSA in serum samples. Results: Total sialic acid and lipid bound sialic acid levels in serum patients with RA show significantly increased when compared to normal group, and more increased in patients with high activity disease. Conclusions: Based on our results, serum TSA and LSA level would be used as a good marker for discriminating between activities of RA disease. Key words: Rheumatoid Arthritis, sialic acid, and lipid bound sialic acid. | ||
| Keywords | ||
| Rheumatoid arthritis; sialic acid; and lipid bound sialic acid | ||
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