THE RELATIONSHIP BETWEEN THE THYROID HORMONES & SOME IMMUNOLOGICAL PARAMETERS AMONG PATIENTS WITH HYPOTHYROIDISM

Naim AL-Naim, Samira; Abd-Al- Razzak, Shatha; Ahmed, Hassin

	THE RELATIONSHIP BETWEEN THE THYROID HORMONES & SOME IMMUNOLOGICAL PARAMETERS AMONG PATIENTS WITH HYPOTHYROIDISM
AL-TAQANI
Article 1, Volume 25, Issue 2, 2012, Pages 56-61
Authors
Samira Naim AL-Naim; Shatha Abd-Al- Razzak; Hassin Ahmed
Abstract
Hypothyroidism is a term that means a decrease of circulatory T3, T4 and an increase of TSH hormone. The aim of the study was to evaluate the relationship between secretion of thyroid hormones and sensitivity of immunoglobulins & complement in patients with hypothyroidism. The study was conducted in Education Laboratories of Medical City during the period between 1/10/2009 -1/7/2011; on 35 patients with hypothyroidism. Their ages' range between 30-40 years (17males & 18 females); compared with 25 apparently healthy control group (13 males & 12 females), their ages range between 25-35 years. Clinically the patients were examined and thyroid hormones (T3, T4 & TSH) were estimated by RIA besides the level of C3, C4 & total serum levels of Igs which estimated by SRID technique. The study showed that there was a significant decrement in T3 & T4 level in comparison with healthy control group. Furthermore, there was a significant difference between the level of T4 among both patients' sexes (males & females). Moreover, there were significant differences in the level of IgG & IgM in comparison with control group. There were no significant differences in C3 & C4 concentrations in comparison with healthy control. It can be concluded that hypothyroidism results in highly significant reduction in T4 levels which results in highly significant elevation in TSH levels in addition to decrement in IgG & IgM levels (with slightly decrement in IgA , C3 and C4 levels) among hypothyroidism patients in comparison with their levels among healthy control.

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