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HISTOLOGICAL CLASSIFICATION OF CHRONIC MYELOID LEUKAEMIA IN IRAQI PATIENTS | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 5, Issue 1, 2007, Pages 34-39 | ||
| Authors | ||
| Fatima A.S. Al-Rawi; Alaa G. Hussain; Saad S.M. Abadah | ||
| Abstract | ||
| Background: Chronic myeloid leukemia (CML) is a stem cell disorder, which progresses from a “benign” chronic phase to a refractory acute leukemia. It is characterized by the presence of Philadelphia chromosome (Ph), in more than 90% of the cases. Objective: To analyze comparatively histological and cytological features of bone marrow in CML at diagnosis, and to confirm the validity of histologic classification from the clinical point of view. Methods: All cases were retrospectively collected from the Teaching Laboratories of the Medical City during the period of January 1985 and April 1994. Special attention was paid to histopathology of the bone marrow of diagnostic biopsies of 72 patients with chronic myeloid leukemia (CML) at the time of diagnosis prior to any therapy with particular reference to haemopoietic cellularity , megakaryocyte (MKCs) per unit area, reticulin fibrosis, blood vessels per unit area, osteoblast index, and trabecular bone width. Results: Based on the number and morphological characteristics of MKCs, cases were classified into 31 patients with common type-chronic myeloid leukemia (CT-CML), and 41 with increased megakaryocytes (MI-CML). Both groups showed relevant clinical, haematological and histologic differences between them. The MI-CML was characterized by mixed proliferation of neutrophile, eosinophile and basophile series besides the megakaryocytic component , while the CT-CML cases predominantly revealed neutrophilic proliferation. Conclusion: The MI-CML accumulated cases with unfavorable prognostic criteria such as older age, larger spleen, anemia, leucocytosis, thrombocytosis, higher percentage of normoblast, basophile and immature precursors (blast and promyelocyte). Among the quantitative parameters obtained from the bone marrow biopsies the quantitative fibrous tissue was significantly higher in MI-CML cases. Key words: Chronic Myeloid leukemia, Iraqi Patients, Histological Classification. | ||
| Keywords | ||
| Chronic Myeloid Leukemia; Iraqi Patients; Histological Classification | ||
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