ONE-YEAR (PATIENT AND RENAL ALLOGRAFT) SURVIVAL FOLLOWING RENAL TRANSPLANTATION

N. Rifat, Usama; S. Alnasiri, Usama; S. A. Muhsin, Ausama

	ONE-YEAR (PATIENT AND RENAL ALLOGRAFT) SURVIVAL FOLLOWING RENAL TRANSPLANTATION
IRAQI JOURNAL OF MEDICAL SCIENCES
Article 1, Volume 5, Issue 2, 2007, Pages 7-12
Authors
Usama N. Rifat; Usama S. Alnasiri; Ausama S. A. Muhsin
Abstract
Background: Renal transplantation offers a realistic therapeutic option to patients with end-stage renal disease (ESRD). Objective: To evaluate one- year (patient and renal allograft) survival and comparing age and HLA-matching results as possible risk factors. Methods: Fifty (50) patients underwent renal transplantation in the renal transplantation unit of Surgical Specialties Hospital-Baghdad from September 2000 to October 2002. None had diabetes mellitus or clinical evidence of symptomatic cardiac disease. All the transplanted kidneys were from living donors. Direct matching between the serum of recipient and lymphocytes of the donor was negative. HLA class I matching was performed. Recipients were followed for one year following renal transplantation clinically and by regular laboratory tests. Ultrasound and color Doppler examinations were performed when there was evidence of decreased urinary output, allograft dysfunction, or clinical suspicion of rejection. Graft nephrectomy, when needed, was done in the same center. Results: Thirty-nine patients (78%) continued their lives one year following renal transplantation while eleven patients (22%) died during the first year following renal transplantation, due to cardiovascular complications and sepsis. Death following renal transplantation was compared with age and HLA- matching as possible risk factors. The comparison was not statistically significant. In thirty-eight patients (76%) the transplanted kidney was functioning normally after one year from renal transplantation. Twelve (12) patients (24%) needed graft nephrectomy on the basis of clinical picture of acute rejection aided by conventional sonographic and color Doppler examinations. Acute rejection was not confirmed by histopathological examination prior to graft nephrectomy. Conclusions: Cardiovascular disease is common in renal transplant recipients and is a major cause of mortality in this population followed by sepsis. Age of recipient and HLA- matching results were not correlated to the one-year recipient mortality. Key words: Acute rejection, cardiovascular diseases, one-year survival, renal transplantation.
Keywords
Acute rejection; cardiovascular diseases; One; year survival; renal transplantation

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