BLEEDING AND THROMBOSIS IN PATIENTS WITH CHRONIC MYELOGENOUS LEUKEMIA

Sh Mansour, Saad; J Musa, Raad; F Al-Sammerai, Wakas

	BLEEDING AND THROMBOSIS IN PATIENTS WITH CHRONIC MYELOGENOUS LEUKEMIA
IRAQI JOURNAL OF MEDICAL SCIENCES
Article 1, Volume 5, Issue 2, 2007, Pages 28-33
Authors
Saad Sh Mansour; Raad J Musa; Wakas F Al-Sammerai
Abstract
Backgroud: There is considerable variation in the incidence of bleeding and thrombotic complications noted among patients with myeloproliferative disorders (cMPDs). Objective: To explore the rate of thrombotic and hemorrhagic complications in cMPD and to identify parameters that might be associated with these complications. Methods: Fourty five patients with various entities of cMPDs were enrolled in this study, which was conducted from January, 2003 to July, 2004 and involves three medical centers in Baghdad. Additionally, 25 apparently healthy individuals were included as control group. The patients and healthy subjects were submitted for the following investigations; (plasma fibrinogen concentration, factor VIII:C, factor VII:Ag, plasma factor X:Ag and plasma D-Dimers. Results: The total rate of haemostatic complications among cMPD patients was 20 %. These complications was significantly associated with increasing patients' ages (P=0.005) and inversely correlated with the disease duration (r =-315, P<0.05). Factor VII:Ag level was found to be significantly lower in CML patients in comparison to control (P=0.001). Concerning the plasma factor VIII: C, FX:Ag levels and plasma D-Dimer, no association was found between any of these three parameters and the occurrence of thrombohaemorrhagic complications. Conclusion: Bleeding and thrombosis are frequent complications in patients with cMPD. Keywords: bleeding, thrombosis, chronic myelogenous leukemia.
Keywords
Bleeding; Thrombosis; chronic myelogenous leukemia

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