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THE EFFECT OF ETHANOLIC EXTRACT OF CITRULLUS COLOCYNTHIS ON SOME BLOOD PARAMETERS AND REPRODUCTIVE ORGAN WEIGHT WITH HISTOPATHOLOGICAL CHANGES OF MATURE WHITE MICES FEMALES | ||
| AL-TAQANI | ||
| Article 1, Volume 24, Issue 7, 2011, Pages 0-0 | ||
| Abstract | ||
| This study was conducted to investigate the effect of Ethanol extract of Citrullus colocynthis when used at a dose (9.6) mg/kg. body weight on some parameters which were inclubed body weights , reproductive organs ( uterus and ovary ) and some blood parameters and histopathological changes for liver and heart of mature white mice females during different periods ( 2 , 4 , 6 and 8 weeks) daily via drinking water. Results indicated no significant difference of body weights, ovary weights and packed cell volume of all mice treated with a dose of (9.6) mg/kg as compared with control groups. Mean while, results showed significant difference ( p<0.05 ) of uterus weights as well as there significant difference (p<0.01) of white and red blood cells numbers of all treated mice during ( 2, 4 , 6 and 8 weed) daily via drning water. The study was in dicated histopathological changes in liver and heart of female mice treated with a dose ( 9.6) mg/kg body weight also after (8) week of treatment, it was noticed sever necrosis and pyknosis of some liver nuclei, while there was degeneration changes with myocardial necrosis of the heart, and appearance of Oedema in the connective tissues of the subepicardium. | ||
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