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VIRULENCE FACTORS OF STREPTOCOCCUS MUTANS ISOLATED FROM PREGNANT WOMEN WITH ACUTE VAGINITIS | ||
| AL-TAQANI | ||
| Article 1, Volume 24, Issue 7, 2011, Pages 27-34 | ||
| Author | ||
| Mohammed Sh. Jebur | ||
| Abstract | ||
| Streptococcus mutans, known to be an etiologic agent of dental caries, also causes infective endocarditic. In the present study, acute vaginitis samples (vaginal swabs) were investigated from pregnant women patients whom admitted to many hospitals of Delivery and Maternal in Baghdad city. Ages of the women ranged from 20-30 years (only marriage one), while all samples were collected during March to July 2009. One hundred and fifty vaginal swabs were collected and cultured on Blood agar plate, Nutrient agar plates, Chocolate agar plates and MacConkey agar plates, then incubated aerobically and anaerobically for 24 hrs. Bacterial diagnosis were done according to macroscopic, microscopic and biochemical tests. The results of recent study were showed that the prevalence of bacterial acute vaginitis in pregnant women, 18(12%) as positive cases, while no growth was seen in the rest vaginal swabs 132 (88%). Results of bacterial isolation and identification were showed that out of 18 isolates only 8 isolates diagnosed as Streptococcus mutans , Staphylococcus epidermidis 8 isolates, Staphylococcus aureus 6 isolates, and 5 isolates for each Streptococcus agalactiae, Streptococcus salivaris and Proteus spp. Results of blood hemolysis of Strep. mutans isolates as virulence factors were showed that only two isolates (25%) having ability to produce hemolysin enzyme, and noticed that four isolates (50%) of Strep. mutans were having ability to produce extracellular protease enzyme on Mg media. While it have (100%) ability to produce siderophores. Results of antibiotics sensitivity test of Strep. mutans isolates showed that all isolates were resistant (100%)to Ampicillin and Amoxicillin, whereas seven isolates were resistant in a lesser degree (87.5%) to tetracycline and Gentamycin (75%) to Cefotaxime and Ciprofloxacin and (62.5%) to Erythromycin. But also all isolates showed highly sensitivity (100%) to Amoxiclave, Doxicyclin and Ampiclox antibiotics. The study concluded that Strep. mutans isolates were showed moderate prevalence in the distribution of pathogenic microorganism of acute vaginitis. These isolates were having (25%) ability of blood hemolysis, (50%) produce protease enzyme and (100%) siderophores production. Strep. mutans vaginal isolates were appeared high sensitivity(100%) to Amoxiclave, Doxicyclin and Ampiclox antibiotics, but it had 100% resistance to synthetic Penicillin(Ampicillin & Amoxcillin) and there were different susceptibility to rest antibiotics that used in the study. The study recommended that isolation and identification of the causative agent as well as its virulence factors are very important and also using of sensitivity test having high value to set the scientific and medical antibacterial drugs to patients | ||
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