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THE VALUE OF NUCLEAR MORPHOMETRY IN BREAST CARCINOMA | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 5, Issue 3, 2007, Pages 13-17 | ||
| Authors | ||
| Hassanain Abdul Jabbar Hassan Al-Obaidi; Fawzia Fawzi; Zainab Abdul Jabbar Hassan Al-Obaidi | ||
| Abstract | ||
| Background: Breast carcinoma is the most important malignant tumor in female population. There are many indications for the use of adjuvant chemotherapy in its treatment, which need a special selection of patients especially those with high risk &this is judged by several prognostic parameters such as patient’s age, tumor size, histological grade and others. Nuclear morphometry has shown to be a good objective, quantitative method for the evaluation of prognosis, in which the Mean Nuclear Area & Standard Deviation of Nuclear Area showed an increase from the baseline value of normal breast epithelium to invasive carcinoma &found to be strongly correlated with the recurrence rate within 2.5 years. Objective:To evaluate some prognostic parameters of breast carcinoma by the use of computerized nuclear morphometry. Material &Methods: Fifty-four cases of a histologically diagnosed invasive breast carcinoma of ductal type with a known tumor grade, size &patient’s age were reviewed. In each case an average of 5-10 microscopical fields were screened &30 consecutive nuclei were determined at x400 magnification by the use of an image analysis system. Statistical analysis was performed using ANOVA, Tukey’s and t-test. Results: The mean values of nuclear area varied between the three histological grades (grade I, II and III) by using analysis of variance (p>0.01). These values increased with increasing histological grade, (Tukey’s test: p>0.01). Similarly the mean values of nuclear area were significantly higher in tumors measuring more than 5cm in diameter than those less than 5cm in diameter. (t-test :p>0.01). On the other hand, the nuclear area in tumors of patients less than 50 years and more than 50 years of age showed no significant difference. (t-test: p<0.01) Conclusions: The Mean Nuclear Area was of value in the assessment of the histological grade, in which higher figures seen in higher grades. The same relationship found between tumors more than 5cm and those less than 5cm in diameter, in which higher values seen in tumors more than 5cm in diameter. On the contrary the importance of the Mean Nuclear Area was restricted when comparing tumors in patients less than 50 years and those more than 50 years of age. In conclusion our data suggest that adapting a nuclear morphometric parameter e.g. nuclear area, which was performed on this study, may be a valuable objective tool in evaluating various prognostic indices. Keywords: Breast carcinoma, nuclear morphometry , and prognosis. | ||
| Keywords | ||
| breast carcinoma; nuclear morphometry; and prognosis | ||
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